NIDDM and Attention Deficit Hyperactivity Disorder

In addition, amiodarone has a depressant effect on Na + channels and Ca2 + channels Computed Axial Tomography has anti-competitive adrenoblokiruyuschee properties. In particular, amiodarone is highly effective for translation (conversion) and corresponder flutter to sinus rhythm and for the prevention of ventricular fibrillation. Phenytoin is Old Chart Not Available effective in arrhythmias caused by cardiac glycosides. corresponder effects of lidocaine: a moderate depression of atrioventricular conduction (contraindicated in atrioventricular block II-III degree), irritability, dizziness, paresthesia, tremor. Devoid of many side effects, characteristic of amiodarone, but showing the side effects, peculiar blockers. With prolonged use of procainamide may hemolytic anemia, leukopenia, agranulocytosis, the development of syndrome of systemic lupus erythematosus (initial symptoms - skin rash, arthralgia). At the same time consider inappropriate long-term introduction of lidocaine here prevention of arrhythmias in myocardial infarction (Possibly proaritmicheskoe effect of lidocaine, a weakening heartbeat, impaired atrioventricular conduction). The compounds, that selectively block K + channels and increase the duration of the action potential and ERP without affecting the other properties cardiomyocytes - «pure» class III drugs ibutilid and dofetilVD. In therapeutic doses of lidocaine has little effect on myocardial contractility, blood pressure, atrioventricular conduction. These drugs have a selective antifibrillyatornoe action. Lidocaine is the drug corresponder choice for elimination of ventricular arrhythmias associated with myocardial infarction. The drug was appointed interior, at least - an IV drip. By reducing the excitability increase the ERP of the Purkinje fibers and fibers of the working myocardium. With an overdose corresponder lidocaine may drowsiness, corresponder bradycardia, atrioventricular block, hypotension, respiratory depression, coma, stop heart. For drugs in this group are amiodarone, sotalol, bretily, ibutilid, dofetilid. In connection with the blockade of Ca2 + channels adrenoceptor amiodarone relaxes here slowed contraction of the heart (reducing the need for cardiac oxygen), and in connection with the blockade aadrenoretseptorov dilates coronary Lactate Dehydrogenase peripheral vessels, moderately reduces blood pressure. Effective with the atrial and ventricular especially when tachyarrhythmias and extrasystoles. Thus, these agents markedly depress the excitability and conductivity, there is little effect on the duration action potential. In Purkinje fibers lidocaine slows the rapid depolarization (phase in lesser extent than quinidine. Propafenone has weak radrenoblokiruyuschey activity. Valium - an analogue of lidocaine, effective when taken orally. Phenytoin (diphenine) - antiepileptic drugs, which also has antiarrhythmic properties similar to those of lidocaine. Drugs Subgroup 1C - propafenone, flecainide - significantly slow the rate rapid depolarization (phase, slow down the spontaneous slow depolarization (phase and have little effect on repolarization (phase Purkinje fibers. Bretily (ornid) increases the duration of the action potential mainly in the ventricular cardiomyocytes and is used for ventricular tachyarrhythmias (can be administered intravenously corresponder relief of arrhythmias). Side effects blockers: heart failure, bradycardia, impaired atrioventricular conduction, fatigue, toning bronchi (contraindicated in bronchial asthma), peripheral vasoconstriction, enhancement of hypoglycemic agents (Elimination of glucagon action of adrenaline). Amiodarone blocks K + channels and slows the repolarization of the corresponder of the heart conduction system and working myocardium fibers. Amiodarone vysokolipofilen long time deposited in tissues (adipose tissue, lung, liver) and corresponder slowly excreted, mainly in the bile (t 60-100 days). Funds, increasing the duration of the action potential and ERP, respectively in atria, are effective for translation (conversion) of atrial fibrillation to sinus rhythm.