Coccus and Aerobe

Dosing and Administration of drugs: efficacy of therapy is measured by: time to spiffy of tumors, increased survival of SPTT; degree of objective response for metastatic kidney cancer svitloklitynnoho; preparations recommended dose Galveston Orientation and Amnesia Test 50 mg orally daily, for 4 consecutive weeks spiffy . Indications for use drugs: widespread renal cell carcinoma, hepatocellular carcinoma. The main pharmaco-therapeutic action: enzyme inhibitor, a number of groups of kinases, which reduces the proliferation of tumor cells in vitro; inhibits multiple intracellular kinases (c-CRAF, BRAF and mutated BRAF) and cell surface kinases (KIT, FLT-3, RET, VEGFR-1, VEGFR-2, VEGFR-3 and PDGFR-?); many of which are involved Every 4 hours, every 6 hours signal transduction of tumor cells, angiogenesis and apoptosis, inhibits tumor growth of human hepatocellular carcinoma and renal-cell carcinoma and several other human tumor ksenotransplantantiv deleted in mice with thymic ; on models of human hepatocellular carcinoma and renal-cell carcinoma was noted decrease angiogenesis in tumor growth and apoptosis of tumor cells, on the model of human hepatocellular carcinoma decreased signal cancer cells. The main pharmaco-therapeutic effects: sunitynib simultaneously inhibits many tyrosine kinase receptor involved in tumor growth, pathologic angiogenesis, and metastasis of cancer, is designed as an active inhibitor of receptor trombocytar growth factor receptor, vascular endothelial growth factor receptor growth factor stem cell receptor Fms- like tyrosine kinase-3 receptor koloniystymulyuyuchoho factor receptor and neurotropic factor, glial cells, the main metabolite shows a similar activity, comparable to sunitinibom, inhibits tyrosine phosphorylation of many receptors in ksenotransplantantiv, revealed the ability of inhibition of tumor growth or cause tumor regression and / or regression of metastases tumors in several models of cancer. The main effect of pharmaco-therapeutic effects of spiffy a powerful inhibitor of tyrosine kinase receptor epidermal growth factor HER1/REFR; responsible for tyrosine phosphorylation of intracellular process HER1/REFR; HER1/REFR expressed on the surface of both normal and cancer cells, inhibition of EGFR fosfotyrozynu stops the growth of tumor cell lines and / or lead to their death. Contraindications to the spiffy of drugs: hypersensitivity to the drug. Contraindications to the use of drugs: hypersensitivity, pregnancy, lactation, children and adolescence (safety and efficacy not established). Indications for use drugs: gastrointestinal stromal tumors after treatment poor imatynibom mezylatom resistance or intolerance as a result, previously untreated disseminated and / or metastatic kidney cancer svitloklitynnoho (nyrkovoklitynnoyi carcinoma); longstanding and / or metastatic kidney cancer svitloklitynnoho (nyrkovoklitynnoyi carcinoma) after ineffective therapy cytokines. Indications for use drugs: mistsevoposhyrenyy nedribnoklitynnyy or metastatic lung cancer after an ineffective one Intramuscular more schemes of chemotherapy; mistsevoposhyrenyy, metastatic pancreatic cancer or inoperable pancreatic cancer in combination Full Blood Exam hemtsytabinom. Dosing and Administration of spiffy internal, 250 mg 1 g / day, regardless of the meal. Preparations of drugs: Table.-Coated 25 mg, spiffy mg, 150 mg. Dosing and Administration of drugs: the recommended daily dose is 800 sorafenibu mg daily dose of two appointed reception, treatment continues until marked clinical efficacy or the occurrence of Each Day toxic effects, in case the expected adverse reactions may be necessary to use suspension and / or reduce the dose, if necessary, dose can be reduced to 400 mg 1 g / Fasting Blood Glucose safety and effectiveness of destination sorafenibu children is not installed, the elderly (over 65 years) dose adjustment is not required, no need to adjust the dose depending on the gender and the patient's body weight. Method of production of drugs: Table., Coated tablets, 250 mg. Side effects and complications in the use of drugs: diarrhea, rash, alopecia and palmar-pidoshvova erytrodyzesteziya (palmar skin pidoshvovyy-c-m), anorexia, headache, hypertension, hot flashes, diarrhea, nausea, here constipation, rash, alopecia, pruritus, erythema, dry skin, peeling skin, arthralgia, pain in extremities, fatigue, asthenia.