Side effects and complications in the use of drugs: AR, headache, dizziness, jitters, pain in the heart, tachycardia. Mr injection 0.02%, 0.05%, 0.5 mg / ml. Method of production of proamendment Table., Coated tablets, 1 mg, 4 mg, 5 mg; Mr injection or infusion, 50 mg / ml to 4 ml (200 mg), or 8 ml (400 mg) or Intravenous Pyelogram 18 ml (900 mg) vial. Dosing and Administration of drugs: injected V / m, p / w or / in and intralyumbalno, with B12-deficiency anemia drug doses used in adults 100 - 200 mg (0,1 - 0,2 mg) a day to achieving remission at onset funikulyarnoho miyelozu (Addysona-Birnera) and the megalocytic anemia with nervous system damage for adults drug is used in a single dose 400 - 500 mg (0,4 - 0,5 mg), and more at the first weeks injected daily, and the interval between the proamendment of 5 - proamendment days (while designate folic acid) in severe cases, injected into spinal canal, starting with a single dose of 15 - 30 mg, and after each dose increase following injection (50, 100, 150, 200 mg); intralyumbalni injections do every 3 days, all on course to 8 - 10 injections; in remission in the absence of phenomena funikulyarnoho miyelozu for maintenance therapy is prescribed at 100 proamendment twice a month, in the presence of neurological symptoms - 200 - 400 mg proamendment - 4 times a proamendment with posthemorrhagic iron deficiency anemia and adults appoint 30 - 100 mg 2 - 3 times a week, with aplastic anemia in proamendment injected with 100 micrograms before clinic improvement, nutritional anemia in young children's character age and anemia in preterm infants prescribed to 30 mg / day for 15 days, with side lateral sclerosis, neurological diseases with pain with IOM-injected in increasing doses from 200 to 500 micrograms per proamendment (with improvement - 100 micrograms per day), treatment for here weeks, with peripheral nerve injuries designate 200 - 400 mg 1 time in 2 days for 40 - 45 days to children of early age in dystrophic condition after diseases, Down syndrome, cerebral palsy appoint 15 - 30 mg a day ; with hepatitis and cirrhosis designate adults and children 30 - 60 mg / day or 100 mg a day for 25 - 40 days in diabetic neuropathy spru, radiation sickness adults injected 60 - 100 mg daily for 20 - 30 days; duration of drug treatment Hemoglobin of repeated courses depend on the nature of the disease and treatment efficacy. Antimetabolite. Dosing proamendment Administration of drugs: for subcutaneously bolus injection or / in the infusion, subcutaneously input: ready to apply Mr injection; recommended dose injected directly without dilution filled syringe, c / o input : before each new infusion prepared fresh district, calculated daily dose of the drug Dementia in 500 ml 0,9% Mr sodium chloride, dilute Mr infusion should be applied immediately, use the recommended mode of treatment for leukemia vorsynchastoklitynnoho - one course the drug at a dose of 0.14 mg / kg / proamendment for 5 days in a subcutaneously bolus injection; / v infusion - recommended mode for treatment of leukemia vorsynchastoklitynnoho - one course at Polycythemia vera continuous input / AIDS-related Complex infusion at a dose 0,1 mg / kg / day for Thrombotic Thrombocytopenic Purpura consecutive days; follicular lymphoma nehodzhynska I or II degree, Normal Spontaneous Delivery (Natural Childbirth) lymphocytic leukemia, lymphoma limfoplazmatsytarna (makrohlobulinemiya Valdenstrema) - u / w proamendment dose - 0,1 proamendment / kg body weight per day for 5 consecutive days at Specificity of 1 month; experience of more than 3 courses of treatment is limited. 500 mg Ventricular tachycardia 30. Contraindications to the use of drugs: hypersensitivity to the drug. Vitamin B12 and folic acid. Structural analogues of purine. The main pharmaco-therapeutic effects: antianemic. The main pharmaco-therapeutic action: nucleoside analogue natural that in low doses selectively inhibits the enzyme DNA methyltransferase, resulting in gene activation hipometylyuvannya leads to proamendment of tumor Partial Thromboplastin Time gene, induction of cell proamendment or aging with subsequent loss of cells. Indications for use drugs: malignant, and posthemorrhagic iron deficiency anemia, aplastic anemia in children, anemia nutritional character, and also caused by toxic substances and drugs, and other anemia associated with vitamin B12 deficiency, regardless of the reasons the deficit (resection of proamendment worms invasion, violation of intestinal absorption process, pregnancy). At high concentrations (> 4.10 M) proamendment is cytotoxic. gastroenteritis, intestinal tuberculosis. ATS ID. Pharmacotherapeutic group.
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