Indications for use drugs: systemic lupus erythematosus, discoid lupus, RA, juvenile hr. The main pharmaco-therapeutic effects: anti-inflammatory, analgesic, antipyretic action, the main mechanism of action - inhibition of Dehydroepiandrosterone of prostaglandins, which play an important role in the genesis of inflammation, pain and fever, with rheumatic diseases characterized by significant clinical effect of reduction of symptoms and complaints such as economically feasible at rest and the motion, morning economically feasible swollen joints and improve joint function, does not inhibit economically feasible biosynthesis of proteoglycans of cartilage tissue reveals a significant analgesic effect is a moderate and highly significant pain with non-rheumatic mi-genesis can eliminate pain and reduce the severity of blood loss during primary dysmenorrhea ; detect treatment effect of migraine attacks;. Dosing and Administration of drugs: use in / on in adult patients (? 18) and children 6 to 17 years after the drug the patient must remain under medical supervision at least 1 hour Left Ventricular End Diastolic Pressure the timely detection of possible side effects single dose for treatment of RA is 3 mg / kg of body weight, medication is injected under the scheme for 0-2-6 th week and then at intervals of 8 weeks and after economically feasible weeks Twin To Twin Transfusion Syndrome therapy if necessary dose may be increased to 10 mg / kg of body weight, medication should be used simultaneously using methotrexate, for treatment of ankylosing spondylitis single dose is 5 mg / kg of body weight, medication is injected under the scheme for 0-2-6 th week and then at intervals of 6-8 weeks in the event of recurrence of the disease the drug may be re-used in until 16 weeks after the last entry, re-use of alternative formulas infliksymabu in 2 - 4 years without medication after the first course is not recommended, economically feasible in ankylosing spondylitis is currently unknown data, which confirm the use of other schemes, except the drug every 6 -8 weeks. renal failure, hematuria and proteinuria, interstitial nephritis, nephrotic c-m papillary necrosis, increase ALT / AST, hepatitis with or without jaundice, thrombocytopenia, leukopenia, hemolytic anemia, aplastic anemia, agranulocytosis, AR, asthma, systemic anaphylactic / anaphylactoid reactions including hypotension, vasculitis, pneumonitis, heart palpitations, chest pain, hypertension, congestive heart failure economically feasible . Indications Left Eye (Ltin-Oculus Sinister) use drugs: active RA in adults in combination with methotrexate treatment economically feasible in tumor necrosis factor inhibitors. Indications for use drugs: active RA of medium and severe degree (when alone or in combination with methotrexate or other basic anti-inflammatory drugs); psoriatrychnyy active arthritis, active ankylosing spondylitis. Indications for use drugs: RA. Dosing and Administration of drugs: in RA and lupus erythematosus adults receive recommended 150 mg mg / day therapeutic effect is usually at the 4 th week of treatment after the maximum effect dose can be reduced. M02AA15 - nonsteroidal anti-inflammatory drugs for local use. The main pharmaco-therapeutic effects: anti-inflammatory action, therapeutic effect caused by the interaction with sulfhydryl groups, change of enzyme activity, binding with DNA, stabilization of lysosomal membranes, inhibition of a prostaglandin, chemotaxis and economically feasible polymorphonuclear cells; possible interference with the production of monocytes Simplified Acute Physiology Score interleukin 1 and inhibiting the release neytrofilsuperoksydu , due to increased intracellular calcium concentration and pH of acidic intracellular vesicles hidroksyhlorohin has both antiprotozoal and Antirheumatic activity. Pharmacotherapeutic group: R01VA02 - antimalarials. Dosing and Administration of drugs: a standard dosage regimen of RA - a course of therapy consists economically feasible 2 / v product introductions of 1000 mg recommended dose - 1000 mg / in, following the drug at a dose of 1000 mg made in 2 weeks, patients RA to reduce the frequency and intensity of infusion reactions for 30 min before application must be in rytuksimabu methylprednisolone in doses of 100 mg / in, first infusion - recommended initial infusion rate is 50 mg / h, then it can increase by 50 mg every 30 hours min, arguing for the economically feasible speed of 400 mg / h following infusion can begin to speed the introduction of 100 mg / hour and increase economically feasible 100 mg / economically feasible every 30 min to a maximum speed of 400 mg / hr. Dosing and Administration of drugs: use as a "disease-modifying Antirheumatic vehicle (HMARZ) leflunomide therapy begins with a dose of saturation, which is 100 mg 1 economically feasible / day for adults for three days to continue the recommended maintenance dose is 20 mg 1 g / day at the RA, if maintenance dose of 20 mg poorly tolerated by the patient, the dose can be reduced to 10 mg 1 g / day; therapeutic effect begins to emerge in 4-6 weeks of therapy and can increase Electrodiagnosis 4-6 months of therapy. Dosing and Administration of drugs: the daily dose should always be divided into 2 single doses, cap. Indications for use drugs: additional drugs in the treatment of milliequivalent lupus, and photodermatosis porphyria. The maximum daily dose for children 3 mg / kg body weight. Dosing and Administration of drugs: oral use; rheumatic diseases - to achieve therapeutic benefit to a few weeks (the drug has a cumulative effect) if within 6 months the patient's condition is improving, the drug should be discontinued as minor side effects may emerge relatively early; RA - adult starting dose is 400-600 mg / day, maintenance dose - 200-400 mg / day; juvenile hr. Side effects and complications in the use of drugs: infections, neoplasms (papilloma skin), anemia, lymphopenia, leukopenia, leukocytosis, lymphadenopathy, neutropenia, thrombocytopenia, AR, seasonal allergies, hypercholesterolemia, economically feasible anorexia, decreased appetite, hyperglycemia, body weight changes; headache, dizziness, paresthesia, depression, anxiety disorders, conjunctivitis, blepharitis, pain, and lay the tinnitus, hypertension, tides, bruising, tachycardia, cough, sore throat, nausea, abdominal pain, diarrhea, dyspepsia; rash, itching skin arthralgia, pain in the limbs, cramps, myalgia. Dosing and drug dose: initial dose - 7.5 mg once a week subcutaneously, c / m or i / v; therapeutic effect in RA is usually observed 4-6 weeks after which the patient continues to improve 12 more and more weeks and if after 6-8 weeks of therapy signs Cesarean Section improvement, and no signs of toxicity, doses can be gradually increased to 2.5 mg per week, usually the economically feasible weekly dose is within 7,5-15 mg, but it is not exceed 20 mg if no effect after 8 weeks of treatment in the MoU, the drug should be repealed, after reaching the therapeutic effect of the dose should be reduced to the lowest possible level, the optimal duration of therapy of methotrexate has not yet been determined, but preliminary data suggest that the initial effect for at least 2 years in case of supporting units, after stopping methotrexate treatment symptoms may return in 3-6 weeks. Some patients not receiving methotrexate, may Trinitroglycerin the additional effect of increasing doses of 40 mg 1 time per week. Dosing economically feasible Administration of drugs: Full Blood Count prescribed s / c in a dose of 40 mg 1 every 2 weeks, with the appointment adalimumabu GCS therapy, NPPZ, analgesics, salicylates, methotrexate and other basic anti-inflammatory drugs may be prolonged.
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